Suprax (cefixime) is a third-generation oral cephalosporin antibiotic renowned for its broad-spectrum bactericidal activity. It is specifically formulated to target and eliminate a wide range of susceptible Gram-positive and Gram-negative bacteria, making it a cornerstone in outpatient and select inpatient therapeutic regimens. Its extended half-life and high oral bioavailability support convenient once or twice-daily dosing, enhancing patient adherence. Clinicians frequently rely on Suprax for its proven efficacy in treating respiratory, urinary tract, and ENT infections, particularly where beta-lactamase-producing pathogens are suspected.

Features

• Active ingredient: Cefixime
• Drug class: Third-generation cephalosporin antibiotic
• Available forms: Oral tablets (400 mg), chewable tablets (100 mg, 200 mg), and oral suspension (100 mg/5 mL)
• Mechanism: Inhibits bacterial cell wall synthesis, leading to cell lysis
• Spectrum: Broad activity against Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains
• Pharmacokinetics: High oral bioavailability; not significantly affected by food; primarily renal excretion

Benefits

• High clinical cure rates in respiratory, urinary, and ENT infections due to potent bactericidal action
• Convenient dosing regimen (once or twice daily) supports patient compliance and reduces missed doses
• Effective against many beta-lactamase-producing bacteria, reducing the need for combination therapy
• Well-tolerated profile with a lower incidence of severe adverse effects compared to some other antibiotic classes
• Suitable for both adult and pediatric populations (≥6 months), with palatable suspension formulation

Common use

Suprax is indicated for the treatment of infections caused by susceptible strains of designated microorganisms, including acute exacerbations of chronic bronchitis, community-acquired pneumonia, acute otitis media, pharyngitis, tonsillitis, and uncomplicated urinary tract infections. It is also used in the treatment of uncomplicated gonorrhea. Healthcare providers should base therapy on microbiological findings or local epidemiological susceptibility patterns.

Dosage and direction

Adults: The recommended adult dose is 400 mg daily, administered as a single dose or in two divided doses (every 12 hours). For uncomplicated gonorrhea, a single 400 mg dose is standard.
Pediatric patients (≥6 months): 8 mg/kg/day, administered as a single daily dose or in two divided doses (every 12 hours). Maximum daily dose should not exceed 400 mg.
Administration: May be taken with or without food. Tablets should be swallowed whole; chewable tablets must be chewed or crushed. Shake oral suspension well before each use. Complete the full prescribed course even if symptoms improve earlier.

Precautions

Use with caution in patients with renal impairment; dosage adjustment is recommended for creatinine clearance <60 mL/min. May cause Clostridium difficile-associated diarrhea; evaluate if diarrhea occurs. Use during pregnancy only if clearly needed. Exercise caution in breastfeeding women. As with other broad-spectrum antibiotics, prolonged use may result in fungal or bacterial superinfection. Monitor for signs of hypersensitivity reactions.

Contraindications

Hypersensitivity to cefixime, any cephalosporin, or any component of the formulation. Known anaphylactic reaction to penicillins or other beta-lactam antibiotics (cross-sensitivity may occur in up to 10% of patients).

Possible side effect

Common adverse reactions include diarrhea (5–16%), nausea (3–7%), abdominal pain, dyspepsia, flatulence, and headache. Less frequently, rash, urticaria, pruritus, transient elevations in liver enzymes, and vaginitis may occur. Serious but rare side effects include pseudomembranous colitis, anaphylaxis, Stevens-Johnson syndrome, and blood dyscrasias.

Drug interaction

Probenecid may increase and prolong cefixime blood levels. Concurrent use with potent diuretics may increase the risk of nephrotoxicity. May reduce efficacy of oral contraceptives; advise alternative non-hormonal contraception. Antacids containing aluminum or magnesium may reduce absorption; administer Suprax at least 2 hours before or after such products.

Missed dose

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management includes gastric lavage and supportive measures. Hemodialysis may accelerate elimination. There is no specific antidote.

Storage

Store tablets and chewable tablets at controlled room temperature (20–25°C or 68–77°F). Keep oral suspension refrigerated (2–8°C or 36–46°F); discard unused portion after 14 days. Keep all forms in their original container, tightly closed, and protected from light and moisture. Keep out of reach of children.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis and individualized treatment recommendations. Do not self-medicate or alter dosages without medical supervision.

Reviews

Suprax is highly regarded in clinical practice for its reliable efficacy, convenient dosing, and generally favorable tolerability. Physicians appreciate its utility in treating common community-acquired infections, particularly in penicillin-allergic patients (with caution). Some note gastrointestinal side effects as a limitation but overall consider it a valuable therapeutic option. Patient feedback often highlights the ease of once-daily dosing and effectiveness in resolving infections, though taste of the suspension can be a concern for some pediatric patients.