Ponstel (mefenamic acid) is a prescription nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of moderate pain and primary dysmenorrhea. As a fenamate-class NSAID, it works by inhibiting prostaglandin synthesis, which plays a key role in pain and inflammation pathways. This medication is particularly valued for its targeted action in managing menstrual discomfort and acute pain episodes. Proper usage under medical supervision ensures optimal therapeutic outcomes while minimizing risks.

Features

• Active ingredient: mefenamic acid
• Available in 250 mg capsule form
• Prescription-only medication
• Typically supplied in bottles of 100 capsules
• Classified as a nonsteroidal anti-inflammatory drug (NSAID)
• Fenamate subclass with specific prostaglandin inhibition properties
• Manufactured under strict pharmaceutical quality standards
• Brand-name product with established clinical history

Benefits

• Provides effective relief from moderate pain, including menstrual cramps
• Reduces inflammation at the site of pain generation
• Offers rapid onset of action when taken at symptom onset
• Allows for better daily functioning during painful menstrual periods
• May decrease the need for additional pain medication when used appropriately
• Specifically formulated for short-term pain management needs

Common use

Ponstel is primarily prescribed for the treatment of primary dysmenorrhea (painful menstrual periods) and for the relief of moderate pain when therapy will not exceed one week. Healthcare providers may also recommend it for other inflammatory conditions requiring short-term NSAID therapy. The medication is typically used on an as-needed basis rather than as continuous long-term treatment.

Dosage and direction

For adults: The usual dosage for painful menstrual periods is 500 mg as an initial dose, followed by 250 mg every 6 hours as needed, usually starting at the onset of bleeding or associated symptoms. Treatment should not exceed 2-3 days. For other moderate pain: 500 mg initially, then 250 mg every 6 hours as needed for usually not more than 7 days. Always take with food or milk to minimize stomach upset. Do not crush or chew capsules; swallow whole with a full glass of water.

Precautions

• Use the lowest effective dose for the shortest duration possible
• Monitor for gastrointestinal bleeding, especially in elderly patients
• Regular monitoring of renal function is advised during treatment
• May cause dizziness or drowsiness; use caution when operating machinery
• Avoid alcohol consumption during therapy due to increased risk of GI bleeding
• Not recommended for use beyond one week without medical supervision
• Use with caution in patients with hypertension or heart failure
• Regular blood pressure monitoring is recommended during treatment

Contraindications

• History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
• Known hypersensitivity to mefenamic acid or other NSAIDs
• Third trimester of pregnancy
• Active peptic ulcer disease or gastrointestinal bleeding
• Severe renal impairment or advanced kidney disease
• Severe hepatic impairment or active liver disease
• Inflammatory bowel disease

Possible side effects

Common side effects may include: nausea, vomiting, diarrhea, dyspepsia, abdominal pain, dizziness, headache, and nervousness. Less frequent but more serious side effects can include: gastrointestinal ulceration or bleeding, hepatotoxicity, renal impairment, hypertension, heart failure, and severe skin reactions. Contact your healthcare provider immediately if you experience signs of allergic reaction, chest pain, shortness of breath, weakness on one side of the body, slurred speech, or bloody stools.

Drug interaction

Ponstel may interact with: anticoagulants (increased risk of bleeding), other NSAIDs or aspirin (increased GI toxicity), ACE inhibitors/ARBs (diminished antihypertensive effect), diuretics (reduced natriuretic effect), lithium (increased lithium levels), methotrexate (increased methotrexate toxicity), and cyclosporine (increased nephrotoxicity risk). Always inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements.

Missed dose

Since Ponstel is typically taken on an as-needed basis for pain, missing a dose is generally not concerning. If you are on a scheduled dosing regimen and miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for a missed one. Consult your healthcare provider if you have questions about missed doses.

Overdose

Symptoms of overdose may include: lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, coma, or renal failure. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Do not induce vomiting unless instructed by medical personnel. Treatment is supportive and may include gastric lavage, activated charcoal, and appropriate symptomatic measures.

Storage

Store at room temperature (20-25°C or 68-77°F) in a tightly closed container. Keep away from moisture, light, and excessive heat. Do not store in bathroom cabinets where humidity levels fluctuate. Keep out of reach of children and pets. Properly discard any expired or unused medication according to FDA guidelines or through medication take-back programs.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting, changing, or stopping any medication. The complete prescribing information should be reviewed before using Ponstel. Individual results may vary, and not all side effects or interactions are listed here.

Reviews

Clinical studies demonstrate Ponstel’s effectiveness in managing menstrual pain, with many patients reporting significant improvement in symptoms. Healthcare providers often note its specific utility for dysmenorrhea when other NSAIDs provide insufficient relief. Some patients report gastrointestinal side effects as a limitation, while others find the targeted relief outweighs these concerns. Overall satisfaction rates remain positive when used appropriately under medical supervision for indicated conditions.