Phexin (Cefalexin) is a first-generation cephalosporin antibiotic designed to combat a wide spectrum of bacterial infections with high efficacy and a well-established safety profile. It functions by inhibiting bacterial cell wall synthesis, leading to the eradication of susceptible pathogens. Trusted by healthcare professionals globally, Phexin offers reliable treatment for respiratory, skin, urinary tract, and middle ear infections, ensuring rapid symptom relief and reduced risk of complications. Its excellent oral bioavailability and predictable pharmacokinetics make it a frontline choice in both outpatient and inpatient settings.

Features

• Contains cefalexin as the active pharmaceutical ingredient
• Available in 250 mg, 500 mg, and 1 g capsules, tablets, and oral suspension formulations
• Exhibits bactericidal activity against Gram-positive and some Gram-negative organisms
• Rapid absorption with peak serum concentrations achieved within 1 hour post-administration
• Demonstrated stability in gastric acid, allowing for consistent oral absorption
• Manufactured under strict pharmaceutical quality control standards

Benefits

• Effectively eliminates common bacterial pathogens, reducing infection duration and severity
• Minimizes the risk of secondary complications through prompt and targeted antimicrobial action
• Supports high patient compliance due to convenient dosing schedules and generally good tolerability
• Provides flexible dosing options suitable for pediatric, adult, and geriatric populations
• Helps prevent the development of resistant strains when used appropriately according to susceptibility testing
• Contributes to shorter recovery times and earlier return to daily activities

Common use

Phexin is indicated for the treatment of bacterial infections caused by susceptible strains of microorganisms. Common uses include pharyngitis, tonsillitis, otitis media, respiratory tract infections such as bronchitis and pneumonia, skin and soft tissue infections including cellulitis and impetigo, bone infections, and genitourinary tract infections including cystitis and prostatitis. It is also used as surgical prophylaxis in certain procedures. Diagnosis should be confirmed via culture and susceptibility testing where possible to ensure appropriate use.

Dosage and direction

Dosage must be individualized based on the infection’s type, severity, and the patient’s renal function. For adults, the usual dose is 250 mg to 1 g every 6 hours, or 500 mg every 12 hours for less severe infections. For children, the recommended dose is 25–50 mg/kg/day divided into four doses. In severe infections, the dosage may be doubled. Phexin is best absorbed when taken on an empty stomach, but may be taken with food to reduce gastrointestinal upset. The oral suspension should be shaken well before each use. Complete the full prescribed course even if symptoms improve earlier to prevent recurrence and resistance.

Precautions

Before using Phexin, inform your healthcare provider of any history of gastrointestinal disease, particularly colitis, or renal impairment. Use with caution in patients with a history of hypersensitivity to penicillins or other beta-lactam antibiotics due to potential cross-reactivity. Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi; monitor for superinfection. In patients with renal impairment, dosage adjustment is necessary—creatinine clearance should guide dosing intervals. Pregnancy Category B: use only if clearly needed. Exercise caution when administering to nursing mothers.

Contraindications

Phexin is contraindicated in patients with known hypersensitivity to cefalexin, cephalosporin antibiotics, or any component of the formulation. Do not use in individuals with a history of severe immediate hypersensitivity reactions (e.g., anaphylaxis) to beta-lactam antimicrobials.

Possible side effect

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, dyspepsia, and dizziness. Less frequently, patients may experience headache, fatigue, vaginitis, genital pruritus, and transient elevations in liver enzymes. Allergic reactions such as rash, urticaria, and pruritus may occur; discontinue use if severe skin reactions or signs of hypersensitivity develop. Rare but serious adverse effects include pseudomembranous colitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and hematologic effects such as neutropenia or positive Coombs test.

Drug interaction

Probenecid may inhibit renal excretion of cefalexin, increasing serum levels and prolonging half-life. Concurrent use with potent diuretics (e.g., furosemide) may enhance nephrotoxicity. Phexin may reduce the efficacy of oral contraceptives; advise alternative contraception during therapy. Concomitant use with other nephrotoxic agents (e.g., aminoglycosides) should be monitored closely. False-positive reactions for glucose in the urine may occur with Benedict’s or Fehling’s solutions; use glucose oxidase methods for accurate testing.

Missed dose

If a dose is missed, take it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up. Consistent timing helps maintain effective antibiotic concentrations in the body.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. In cases of significant overdose, gastric lavage and supportive measures are recommended. Hemodialysis may aid in removing cefalexin from the bloodstream. Manage symptoms symptomatically; no specific antidote exists.

Storage

Store at room temperature (15–30°C), in a dry place, protected from light and moisture. Keep the oral suspension refrigerated after reconstitution and discard any unused portion after 14 days. Keep all medications out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or changing your treatment plan. The prescribing physician should be guided by official prescribing information and local guidelines.

Reviews

Clinical studies and post-marketing surveillance demonstrate Phexin’s consistent efficacy and safety. In a multicenter trial involving patients with skin and soft tissue infections, Phexin achieved clinical cure rates of over 90%. Patients and physicians frequently report satisfactory outcomes, rapid symptom resolution, and good tolerability. Some users note mild gastrointestinal effects, which often subside with continued use or administration with food. Overall, Phexin remains a trusted option in empirical and culture-directed antibiotic therapy.