Gyne-Lotrimin is a leading over-the-counter antifungal medication specifically formulated to treat vaginal yeast infections caused by Candida albicans. Its active ingredient, clotrimazole, functions by disrupting the cell membrane integrity of fungal organisms, leading to their eradication. This topical cream provides targeted, localized therapy with minimal systemic absorption, making it a first-line choice for uncomplicated vulvovaginal candidiasis. Trusted by healthcare professionals and patients alike, it offers a convenient, effective solution for symptomatic relief and mycological cure.

Features

• Contains 2% clotrimazole as the active antifungal agent
• Available in a 1 oz (28 g) tube with measured-dose applicator
• Water-miscible, hypoallergenic cream base
• Designed for intravaginal and external vulvar application
• Formulated at pH levels compatible with vaginal mucosa
• Paraben-free and dye-free formulation

Benefits

• Rapid symptomatic relief from itching, burning, and irritation within days of initiation
• High mycological cure rates demonstrated in clinical studies
• Minimal systemic absorption reduces risk of drug interactions
• Dual-action formulation treats both internal and external symptoms
• Pre-measured applicator ensures proper dosage and hygienic administration
• Over-the-counter accessibility allows for prompt treatment initiation

Common use

Gyne-Lotrimin is indicated for the local treatment of vulvovaginal candidiasis. Typical symptoms include vulvar pruritus, erythema, swelling, dyspareunia, external dysuria, and abnormal vaginal discharge characterized as white, clumpy (cottage cheese-like), and odorless. It is most effective for uncomplicated infections in immunocompetent, non-pregnant patients. Healthcare providers may recommend it for initial episodes or recurrent infections when diagnosis is confirmed.

Dosage and direction

Apply intravaginally once daily at bedtime for 3 consecutive days (for the 3-day treatment course) or 7 consecutive days (for the 7-day treatment course). Wash hands before and after application. Remove cap from tube and attach applicator. Squeeze tube from bottom to fill applicator with cream until plunger stops. Lie on back with knees bent and gently insert applicator deep into vagina. Push plunger to release medication. Clean applicator with mild soap and water after each use. External symptoms may be treated by applying a thin layer of cream to affected vulvar areas twice daily.

Precautions

For vaginal use only. Avoid contact with eyes. Discontinue use if sensitivity or irritation develops. Do not use if seal around tube opening is broken. Not for use in children under 12 years. Patients with diabetes mellitus should monitor blood glucose levels closely as hyperglycemia may predispose to fungal infections. Those with compromised immune systems (HIV, chemotherapy, immunosuppressive therapy) should consult physician before use. Avoid simultaneous use with other vaginal products.

Contraindications

Hypersensitivity to clotrimazole or any component of the formulation. Not for use in patients with known sensitivity to imidazole antifungals. Should not be used when abdominal pain, fever, or foul-smelling discharge is present (may indicate alternative diagnoses). Contraindicated in patients with history of anaphylactic reactions to azole antifungals.

Possible side effects

Most common side effects include local burning, itching, irritation, cramping, and skin rash. Less frequently reported effects include headache, urinary frequency, and lower abdominal discomfort. Rare cases of hypersensitivity reactions including hives, swelling, and difficulty breathing have been reported. Systemic effects are uncommon due to minimal absorption.

Drug interaction

Although systemic absorption is minimal, theoretical interactions exist with other vaginally administered products including condoms and diaphragms (may weaken latex). Concurrent use with corticosteroids may increase absorption of clotrimazole. No clinically significant interactions with systemically administered drugs have been established, though caution is advised with other azole antifungals.

Missed dose

Apply as soon as remembered unless close to next scheduled dose. Do not double dose. Maintain regular application schedule. Extended treatment beyond recommended duration is not advised without medical consultation.

Overdose

Topical overdose is unlikely due to limited systemic absorption. Excessive application may cause increased local irritation. If accidentally ingested, seek medical attention immediately. Symptomatic and supportive care is recommended for oral ingestion.

Storage

Store at room temperature (15-30°C or 59-86°F). Do not freeze. Keep tube tightly closed. Keep out of reach of children. Discard 6 months after opening or by expiration date, whichever comes first.

Disclaimer

This product is for the treatment of vaginal yeast infections only. Read entire leaflet before use. Do not use if you have never had a medically diagnosed yeast infection. Consult healthcare provider if symptoms do not improve within 3-7 days, if symptoms return within 2 months, or if you suspect you may be pregnant. Seek immediate medical attention if fever, chills, nausea, vomiting, or foul-smelling discharge occurs.

Reviews

Clinical studies demonstrate mycological cure rates of 85-90% with 3-day therapy and 90-95% with 7-day therapy. Patient-reported satisfaction surveys indicate 88% experienced symptom relief within 3 days of treatment initiation. Dermatological testing confirms low irritation potential and good cutaneous tolerance. The American College of Obstetricians and Gynecologists recognizes clotrimazole as an effective first-line treatment for uncomplicated vulvovaginal candidiasis.