Dramamine (dimenhydrinate) is a leading over-the-counter medication specifically formulated to prevent and treat symptoms associated with motion sickness. As a well-established antihistamine with antiemetic and antivertigo properties, it works by inhibiting signals in the brain responsible for nausea, dizziness, and vomiting. Its efficacy and rapid onset make it a trusted choice for travelers and healthcare professionals alike, providing reliable comfort during various forms of motion-induced discomfort.

Features

• Active Ingredient: Dimenhydrinate (50 mg per tablet in standard formulations)
• Drug Class: Ethanolamine derivative antihistamine (H1-receptor antagonist)
• Formulations: Chewable tablets, liquid-filled capsules, and liquid suspension
• Onset of Action: Typically 30 to 60 minutes after ingestion
• Duration of Effect: Provides relief for approximately 4 to 6 hours per dose
• Non-prescription status for convenient access

Benefits

• Effectively prevents the onset of nausea, vomiting, and dizziness caused by motion.
• Allows for uninterrupted travel and participation in activities on land, sea, and air.
• Reduces the sensory conflict in the brain that is the primary cause of motion sickness symptoms.
• Provides a predictable duration of effect, enabling users to plan dosage around travel schedules.
• Available in various formulations to suit different age groups and patient preferences, including easy-to-swallow options.

Common use

Dramamine is primarily indicated for the prevention and treatment of the symptoms of motion sickness, including nausea, vomiting, and dizziness. It is commonly used by individuals embarking on car rides, boat voyages, flights, or train journeys who are prone to these sensations. It is also sometimes used off-label for the management of vertigo associated with conditions affecting the inner ear, though such use should be discussed with a healthcare provider.

Dosage and direction

For the prevention of motion sickness in adults and children 12 years and older, the standard dose is 50 mg to 100 mg (1 to 2 tablets) taken 30 minutes to 1 hour before travel. This dose may be repeated every 4 to 6 hours as needed, not to exceed 400 mg in 24 hours. For children ages 6 to under 12 years, the dose is 25 mg to 50 mg (½ to 1 tablet) every 6 to 8 hours, not to exceed 150 mg in 24 hours. Do not administer to children under 6 years of age unless directed by a doctor. Always take with food or water to minimize potential stomach upset. For accurate pediatric dosing, especially with liquid formulations, use the measuring device provided.

Precautions

Before using Dramamine, patients should be aware that it may cause drowsiness. It is imperative to avoid operating motor vehicles, machinery, or engaging in activities requiring mental alertness until the individual’s response to the drug is known. Alcohol and other central nervous system (CNS) depressants (e.g., sedatives, tranquilizers) should be avoided as they can intensify drowsiness. Use with caution in patients with a history of asthma, glaucoma, an enlarged prostate, difficulty urinating, or seizures. Elderly patients may be more sensitive to the side effects of this drug, particularly drowsiness, dizziness, and confusion.

Contraindications

Dramamine is contraindicated in individuals with a known hypersensitivity to dimenhydrinate or other ethanolamine-derived antihistamines. Its use is also contraindicated in neonates and premature infants. It should not be used by patients with narrow-angle glaucoma, severe hypertension, severe coronary artery disease, or those taking monoamine oxidase inhibitors (MAOIs), due to the risk of potentiating anticholinergic effects.

Possible side effect

The most common side effect associated with Dramamine is drowsiness. Other frequently reported side effects include:

• Dry mouth, nose, and throat
• Dizziness
• Blurred vision
• Restlessness or excitement (particularly in children)
• Upset stomach or constipation
• Headache Less common but more serious side effects require immediate medical attention and may include:
• Palpitations or irregular heartbeat
• Difficulty urinating
• Mental/mood changes (e.g., confusion, nervousness)
• Ringing in the ears
• Seizures
• Allergic reactions characterized by rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Drug interaction

Dramamine has the potential to interact with several other medications, which can increase the risk of serious side effects. Notable interactions include:

• CNS Depressants: Alcohol, benzodiazepines, opioid pain relievers, muscle relaxants, and sleep medications can lead to profound drowsiness, dizziness, and impaired motor control.
• Anticholinergic Drugs: Concurrent use with other drugs possessing anticholinergic properties (e.g., scopolamine, some antidepressants, medications for Parkinson’s disease) can compound side effects like dry mouth, blurred vision, constipation, and urinary retention.
• Monoamine Oxidase Inhibitors (MAOIs): Concomitant use is contraindicated due to the risk of intensified anticholinergic and CNS effects.
• Apomorphine: Dramamine may diminish the emetic effect of apomorphine. Always inform your healthcare provider of all the products you use, including prescription drugs, non-prescription drugs, and herbal products.

Missed dose

As Dramamine is typically used on an as-needed basis for motion sickness rather than on a fixed schedule, a missed dose is not generally a concern. If you are using it on a scheduled basis for another reason (as directed by a physician) and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

In case of overdose, call a poison control center or seek emergency medical attention immediately. Symptoms of overdose may include severe drowsiness, seizures, palpitations, loss of consciousness, hallucinations, and flushing (especially in children). In severe cases, overdose can lead to respiratory depression and death, particularly in young children. Treatment is supportive and may include gastric lavage, administration of activated charcoal, and management of symptoms.

Storage

Store Dramamine at room temperature (68°F to 77°F or 20°C to 25°C) away from light, moisture, and heat. Do not store in the bathroom. Keep all medications out of the reach of children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

Disclaimer

This information is for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the standard labeling for non-prescription dimenhydrinate and may not be exhaustive.

Reviews

“Dramamine has been a lifesaver for our family cruises. I take it an hour before we board and I can enjoy the entire day without a hint of nausea. It does make me a bit sleepy, but that’s a fair trade-off for being functional.” – Sarah K.

“As a physician, I often recommend Dramamine to my patients who are prone to motion sickness. Its efficacy profile is well-documented, and it provides predictable relief for most individuals. I advise them to try it first in a non-travel setting to assess their tolerance for drowsiness.” – Dr. Evan R.

“I’ve tried other motion sickness pills, but I always come back to Dramamine. It works faster for me. I use the chewable tablets and they start working within 30 minutes. Essential for long car rides through the mountains.” – Mark T.

“I gave this to my 10-year-old as directed by the pediatrician for a school bus trip. It worked perfectly—no vomiting, just a little quiet on the ride home. Will definitely use again for travel.” – Jennifer L.