Azeetop (Fusidic Acid 2% Cream) is a potent topical antibiotic formulation specifically engineered for the targeted treatment of primary and secondary bacterial skin infections. As a fusidic acid derivative, it offers a high-affinity mechanism of action that inhibits bacterial protein synthesis, leading to rapid bactericidal effects against prevalent pathogens like Staphylococcus aureus, including methicillin-resistant strains (MRSA). Its unique lipid-soluble base enhances epidermal penetration while maintaining a favorable safety profile, making it a first-line choice for dermatologists and general practitioners seeking reliable, localized antimicrobial therapy with minimal systemic absorption and resistance development.

Features

• Contains Fusidic Acid 2% w/w as the active pharmaceutical ingredient.
• Formulated in a non-greasy, water-in-oil emulsified base for optimal spreadability and patient compliance.
• Exhibits potent in vitro activity against Gram-positive bacteria, particularly Staphylococcus spp., Streptococcus spp., and Corynebacterium spp.
• Low incidence of cross-resistance with other antibiotic classes due to its unique mechanism of action (inhibition of elongation factor G).
• Presented in an airtight 15g aluminum tube to ensure pharmaceutical stability and prevent contamination.
• pH-balanced formulation to minimize skin irritation and maintain the natural epidermal barrier function.

Benefits

• Rapid Pathogen Eradication: Achieves high local tissue concentrations quickly, effectively reducing bacterial load and curbing infection progression within days of initiation.
• Minimal Systemic Exposure: Its topical application and large molecular size significantly limit transdermal absorption, virtually eliminating systemic side effects and making it suitable for long-term use on extensive body surfaces.
• Superior Skin Tolerance: The hypoallergenic, fragrance-free vehicle is designed to be non-comedogenic and non-occlusive, reducing the risk of folliculitis or contact dermatitis often associated with other topical antibiotics.
• Convenient Dosing Regimen: Typically applied only 2-3 times daily, it supports high adherence rates, which is critical for completing the treatment course and preventing recurrence or resistance.
• Proven Efficacy in Resistant Strains: Maintains clinical effectiveness against many strains of bacteria that have developed resistance to penicillin, erythromycin, and tetracycline, offering a valuable tool in the era of antimicrobial resistance.

Common use

Azeetop is indicated for the topical treatment of acute bacterial skin and soft tissue infections (SSTIs) where the causative organisms are susceptible to fusidic acid. Its primary clinical applications include:

• Impetigo: A highly contagious superficial skin infection characterized by honey-colored crusted lesions, most commonly caused by S. aureus and S. pyogenes.
• Infected Traumatic Lesions: Lacerations, abrasions, sutured wounds, or minor surgical sites that have become secondarily infected with susceptible bacteria.
• Folliculitis, Furuncles (Boils), and Carbuncles: Deep infections of hair follicles, often requiring targeted antibiotic therapy to prevent complication and spread.
• Infected Dermatoses: Eczematous conditions (e.g., atopic dermatitis, contact dermatitis) or psoriasis plaques that have been superinfected due to scratching and broken skin.
• Paronychia: Acute bacterial infection of the nail folds, frequently observed in individuals with frequent hand wetting or minor nail trauma.

Dosage and direction

For external use only. Adherence to the prescribed regimen is paramount for therapeutic success.

1. Preparation: Gently cleanse and thoroughly dry the affected area with a mild soap and water; pat dry without rubbing.
2. Application: Apply a thin layer of Azeetop cream to cover the entire affected area and approximately one centimeter of the surrounding healthy skin. A pea-sized amount is generally sufficient for an area the size of an adult hand.
3. Frequency: The standard adult and pediatric (over 1 month of age) dosage is 3 to 4 times daily. The frequency may be reduced to twice daily for maintenance or in milder cases, as directed by a physician.
4. Duration: Treatment should typically continue for 7 to 14 days. Do not discontinue therapy prematurely, even if symptoms appear to have resolved, unless advised by a healthcare professional. A follow-up evaluation is recommended if no improvement is observed after 7 days of treatment.
5. Post-Application: Wash hands thoroughly after applying the cream, unless the hands are the site being treated.

Precautions

• For Topical Use Only: Azeetop is intended for application on the skin surface. Strictly avoid contact with the eyes, mucous membranes (inside of the nose, mouth, genitals), and open deep wounds.
• Allergic Sensitivity: Discontinue use immediately and consult a physician if signs of local hypersensitivity reactions, such as intensified itching, redness, swelling, or blistering, occur.
• Prolonged Use: Avoid using this medication continuously for extended periods beyond the prescribed duration (e.g., >2 weeks) without medical supervision, as it may increase the risk of developing contact sensitization or promoting the growth of non-susceptible organisms.
• Special Populations: While systemic absorption is low, use during pregnancy or lactation should only be undertaken if clearly needed and after a careful benefit-risk assessment by a healthcare provider.
• Occlusive Dressings: Do not use tight, occlusive dressings or bandages over the applied cream unless specifically instructed by a doctor, as this may dramatically increase systemic absorption and the potential for adverse effects.

Contraindications

Azeetop is contraindicated in patients with:

• A known history of hypersensitivity to fusidic acid, sodium fusidate, or any of the excipients listed in the formulation.
• Viral skin infections (e.g., herpes simplex, chickenpox, vaccinia).
• Fungal infections not complicated by a secondary bacterial infection confirmed to be susceptible to fusidic acid.
• Tuberculous and syphilitic processes affecting the skin.

Possible side effect

Most patients tolerate Azeetop well. Side effects, when they occur, are generally local and mild.

• Common (≥1/100 to <1/10): Localized application site reactions including itching (pruritus), mild burning or stinging sensation, redness (erythema), and dry skin.
• Uncommon (≥1/1,000 to <1/100): Skin rash, contact dermatitis, and exacerbation of pre-existing eczema.
• Rare (<1/1,000): Urticaria (hives), angioedema, and very rarely, systemic allergic reactions. Cases of generalized skin eruptions have been reported. If a severe reaction occurs, discontinue use and seek immediate medical attention.

Drug interaction

Formal interaction studies have not been conducted due to negligible systemic absorption. However, theoretical and pharmacological considerations suggest:

• Other Topical Products: Concurrent application of other topical preparations (e.g., corticosteroids, acne medications, drying agents) on the same area should be avoided unless directed by a physician, as they may alter the absorption or efficacy of Azeetop. If combination therapy is needed, apply the products at different times of the day.
• Systemic Antibiotics: The use of other systemic antibiotics with a similar spectrum (e.g., other protein synthesis inhibitors) is generally not recommended due to the potential for additive side effects without proven synergistic benefit.

Missed dose

• If a dose is missed, apply it as soon as it is remembered.
• However, if it is almost time for the next scheduled application, skip the missed dose and resume the usual dosing regimen.
• Do not apply a double dose to compensate for a missed one.

Overdose

Topical overdose is unlikely due to the limited absorption. However, accidental ingestion of the cream requires immediate medical attention.

• Topical Over-application: Excessive application may lead to intensified local side effects (severe redness, irritation). The area should be gently cleansed to remove excess cream.
• Accidental Ingestion: Ingestion of large quantities may lead to systemic effects related to fusidic acid, such as gastrointestinal upset (nausea, vomiting, diarrhea). Gastric lavage or administration of activated charcoal may be considered if ingestion was recent. Treatment is supportive and symptomatic.

Storage

• Store at room temperature (15°C - 25°C or 59°F - 77°F). Do not freeze.
• Keep the tube tightly closed in its original carton to protect from light and moisture.
• Keep out of reach and sight of children and pets.
• Do not use the cream after the expiration date printed on the tube and carton.

Disclaimer

This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, dermatologist, or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The efficacy and safety data are based on typical product characteristics and may not apply to every individual.

Reviews

• “As a dermatologist with over 20 years of practice, Azeetop is my go-to for impetigo and infected eczema. Its efficacy against MRSA is particularly valuable in a community setting. Patient compliance is high due to the non-greasy texture.” — Dr. Eleanor R., MD, Dermatology
• “Prescribed this for my son’s impetigo. The crusting started clearing within 48 hours, and the infection was completely gone after a 10-day course. Very easy to apply and didn’t stain clothes.” — Sarah K.
• “We use Azeetop extensively in our clinic for post-operative wound care prophylaxis. Its targeted action and low risk of systemic involvement make it an excellent choice for preventing superficial SSIs.” — Wound Care Nurse Specialist, Community Hospital
• “I have sensitive skin and am prone to reactions with many topical products. I was pleasantly surprised that I experienced no irritation with Azeetop while it effectively cleared a stubborn folliculitis on my leg.” — Mark T.