Aygestin (norethindrone) is a prescription progestin medication used to treat a variety of gynecological and hormonal conditions. As a semi-synthetic form of the naturally occurring hormone progesterone, it provides targeted hormonal regulation. It is most commonly prescribed to address abnormal uterine bleeding, amenorrhea, and endometriosis. Its mechanism of action involves altering the uterine lining and modulating the body’s hormonal environment, offering a non-estrogen based therapeutic option for patients requiring progestin-specific treatment.

Features

• Active Ingredient: Norethindrone
• Drug Class: Progestin
• Administration: Oral tablet
• Available Strengths: 5 mg
• Prescription Status: Rx-only
• Manufacturer: Various pharmaceutical companies under FDA approval

Benefits

• Effectively manages and reduces abnormal uterine bleeding by stabilizing the endometrial lining.
• Provides a reliable treatment option for secondary amenorrhea, helping to restore regular menstrual cycles.
• Alleviates pain and slows the progression of endometriosis by suppressing endometrial tissue growth outside the uterus.
• Offers a progestin-only hormonal therapy option for patients who cannot tolerate or should avoid estrogen.
• Can be used as a diagnostic tool to assess endogenous estrogen production.
• Provides a targeted approach to hormonal regulation with a well-established safety profile.

Common use

Aygestin is primarily indicated for the treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology. It is commonly prescribed for secondary amenorrhea (absence of menstrual periods in women who previously had regular cycles) and for management of endometriosis-associated pain. Healthcare providers may also use it off-label for other conditions requiring progestin therapy, such as endometrial hyperplasia prevention or as part of fertility treatments. It is specifically valuable for patients who require progestin effects without estrogen components.

Dosage and direction

Dosage varies significantly based on the condition being treated and individual patient response. For abnormal uterine bleeding: 2.5 to 10 mg daily for 5 to 10 days during the second half of the menstrual cycle. For amenorrhea: 2.5 to 10 mg daily for 5 to 10 days. For endometriosis: 5 mg daily for 14 days, may be increased gradually up to 15 mg daily. Always take exactly as prescribed by your healthcare provider, typically at the same time each day to maintain consistent hormone levels. Tablets should be swallowed whole with water, with or without food.

Precautions

Patients should undergo thorough medical evaluation before starting Aygestin. Regular monitoring of liver function, blood pressure, and cholesterol levels is recommended during treatment. Use with caution in patients with history of depression, diabetes, asthma, migraine, epilepsy, or cardiac/renal dysfunction. May cause fluid retention; use cautiously in patients with conditions that might be aggravated by fluid retention (e.g., epilepsy, migraine, asthma, cardiac dysfunction). Patients should be monitored for signs of thrombotic disorders. Not recommended for long-term continuous use without periodic evaluation.

Contraindications

Aygestin is contraindicated in patients with known hypersensitivity to norethindrone or any component of the formulation. Absolute contraindications include: known or suspected pregnancy, undiagnosed abnormal genital bleeding, known or suspected breast cancer, active thrombophlebitis or thromboembolic disorders, history of these conditions, acute liver disease or liver tumors, and missed abortion. Relative contraindications include history of depression, hypertension, diabetes mellitus with vascular involvement, and cholestatic jaundice of pregnancy.

Possible side effect

Common side effects (≥5% incidence) include: nausea, headache, dizziness, breast tenderness, irregular bleeding patterns, weight changes, fluid retention, and mood changes. Less common but serious side effects requiring immediate medical attention include: sudden vision changes, severe headache, speech problems, chest pain, shortness of breath, severe abdominal pain, jaundice, depression with suicidal ideation, and signs of allergic reaction. Most side effects are dose-dependent and may diminish with continued use or dosage adjustment.

Drug interaction

Aygestin may interact with numerous medications including: CYP3A4 inducers (rifampin, barbiturates, carbamazepine, phenytoin) which may decrease efficacy; anticoagulants (warfarin) requiring dosage adjustment; insulin and oral hypoglycemics may require dosage modification; corticosteroids may have enhanced effects; and certain antibiotics may affect enterohepatic circulation. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. If multiple doses are missed, contact your healthcare provider for guidance, as breakthrough bleeding may occur. The specific protocol may vary based on the treatment indication and timing within the cycle.

Overdose

There have been no reports of serious ill effects from overdose. Possible symptoms may include nausea, vomiting, and drowsiness. In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Treatment should be symptomatic and supportive. No specific antidote exists.

Storage

Store at controlled room temperature (20-25°C or 68-77°F). Keep in original container, tightly closed. Protect from light and moisture. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Do not flush medications down the toilet or pour down a drain unless instructed to do so.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication regimen. Individual results may vary. The information provided is not exhaustive and should not be used as a substitute for professional medical advice, diagnosis, or treatment.

Reviews

Clinical studies and patient reports generally indicate positive outcomes for indicated uses. Many patients report effective control of abnormal bleeding and endometriosis symptoms. Some note side effects including mood changes and weight fluctuations. Healthcare providers typically consider it an effective option within its therapeutic class when appropriately prescribed and monitored. Patient satisfaction often correlates with proper patient selection and management of expectations regarding side effects.