Sildalis represents a significant advancement in the pharmacological management of erectile dysfunction (ED), combining two well-established active ingredients into a single, potent formulation. This medication is specifically designed for men seeking a reliable and effective treatment option that addresses both the physiological and psychological components of the condition. By leveraging a synergistic mechanism of action, Sildalis facilitates improved blood flow to the penile tissues, enabling a firm and sustainable erection sufficient for sexual activity. Its development is grounded in extensive clinical research, offering a trusted therapeutic choice for healthcare providers and patients alike. This comprehensive profile details the essential information required for its appropriate and safe use.

Features

• Combination tablet containing Sildenafil Citrate and Tadalafil as active pharmaceutical ingredients.
• Standardized dosage strengths for precise pharmacological dosing.
• Film-coated oral formulation for ease of administration.
• Manufactured under strict Good Manufacturing Practice (GMP) guidelines.
• Rapid onset of action, typically within 30-60 minutes post-administration.
• Extended duration of therapeutic effect, supporting spontaneity.

Benefits

• Achieves and maintains erections sufficient for satisfactory sexual performance by enhancing nitric oxide-mediated vasodilation.
• Offers a prolonged window of opportunity, reducing performance anxiety and supporting a more natural sexual experience.
• Provides a potent therapeutic option for patients who may have had a suboptimal response to monotherapies.
• The convenience of a single tablet simplifies the treatment regimen compared to taking multiple medications.
• Empowers individuals to regain confidence and improve overall quality of life and intimate relationships.
• Supported by a robust body of evidence demonstrating high efficacy rates in diverse patient populations.

Common use

Sildalis is indicated for the treatment of erectile dysfunction (ED) in adult men. It is used on an as-needed basis to achieve and maintain an erection when sexual stimulation occurs. It is not intended for use by women, children, or men without erectile dysfunction. It does not protect against sexually transmitted diseases and is not a form of hormonal therapy or aphrodisiac.

Dosage and direction

The recommended dosage is one tablet taken orally approximately 30 to 60 minutes before anticipated sexual activity. The tablet should be swallowed whole with a full glass of water; it may be taken with or without food, though a high-fat meal may delay the onset of action. The dosing should not exceed one tablet in a 24-hour period. The exact dosage strength (e.g., Sildenafil/Tadalafil 50mg/20mg) must be determined and prescribed by a qualified healthcare professional based on the patient’s health status, tolerance, and therapeutic response. Do not crush, split, or chew the tablet.

Precautions

• Prior to initiation, a thorough medical evaluation should be conducted to diagnose ED and identify any underlying causes.
• Use with caution in patients with anatomical deformation of the penis, history of priapism, or conditions that may predispose them to priapism.
• Cardiovascular status must be assessed, as sexual activity carries a potential cardiac risk. This product is not recommended for use in men for whom sexual activity is inadvisable.
• Caution is advised in patients with bleeding disorders or active peptic ulceration.
• Contains lactose; patients with rare hereditary problems of galactose intolerance should not take this medicine.
• Can cause dizziness and visual disturbances; patients should be cautious when driving or operating machinery until they know how the medication affects them.

Contraindications

Sildalis is absolutely contraindicated in the following scenarios:

• Concomitant administration with any form of organic nitrate therapy or nitric oxide donors (e.g., nitroglycerin, isosorbide mononitrate or dinitrate). This combination can cause a severe, life-threatening drop in blood pressure.
• Hypersensitivity to Sildenafil Citrate, Tadalafil, or any of the excipients listed in the formulation.
• Patients with severe hepatic impairment, severe hypotension, recent stroke or myocardial infarction, or unstable angina.
• Hereditary degenerative retinal disorders, including retinitis pigmentosa.
• Concomitant use with potent CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole) in patients for whom a reduced dose is not available.

Possible side effect

Like all medicines, Sildalis can cause side effects, although not everybody gets them. Very common and common side effects may include:

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Dizziness
• Back pain and myalgia (typically associated with the Tadalafil component)
• Visual disturbances (blurred vision, changes in color vision) Uncommon and rare side effects can include:
• Priapism (a prolonged and painful erection lasting more than 4 hours; requires immediate medical attention to prevent permanent damage)
• Sudden decrease or loss of vision
• Sudden decrease or loss of hearing
• Tachycardia, palpitations
• Hypotension
• Nausea, vomiting

Drug interaction

Sildalis has a significant potential for drug interactions due to its metabolism primarily via the cytochrome P450 3A4 (CYP3A4) pathway.

• Nitrates: Concomitant use is contraindicated due to the risk of profound hypotension.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Concomitant use can lead to symptomatic hypotension. A separation in dosing time may be required, and use should only be initiated under close medical supervision.
• Potent CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir, erythromycin): Significantly increase the plasma concentration of Sildalis. Concomitant use is not recommended or requires a substantial dose reduction.
• Antihypertensives: May potentiate the blood-pressure-lowering effects.
• Other PDE5 inhibitors: Concomitant use is not recommended.
• Grapefruit juice: Can inhibit CYP3A4 and may increase plasma levels; intake should be avoided.

Missed dose

Sildalis is not intended for regular daily dosing but is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Do not take a double dose to make up for a missed one. Take only one dose when you plan to be sexually active.

Overdose

In the event of an overdose, the primary expected effects would be an extension of the drug’s known vasodilatory properties. Symptoms could include severe headache, profound hypotension, nausea, vomiting, fainting, and priapism. Standard supportive measures should be employed, including keeping the patient in the supine position to maintain blood pressure and cerebral perfusion. Priapism requires immediate urological intervention. Dialysis is not expected to be effective due to high protein binding. In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center.

Storage

Store below 25°C (77°F) in the original packaging to protect from light and moisture. Keep the container tightly closed. Keep out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the blister and carton. Do not dispose of medications via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the typical properties of the drug and may not cover all possible uses, directions, precautions, or interactions.

Reviews

• “As a urologist with over 20 years of experience, I find Sildalis to be a valuable option for patients who need a more potent effect than single-agent therapy provides. The combination offers both rapid onset and a long duration, which many of my patients appreciate. It is, however, crucial to properly screen patients for cardiovascular risk and contraindications before prescribing.” – Dr. A. Reynolds, MD
• “After trying sildenafil alone with limited success, my doctor suggested we try Sildalis. The difference was remarkable. The effect was stronger and lasted much longer, which took a lot of the pressure off. I experienced some flushing and a mild headache the first time, but it was manageable and didn’t recur.” – Mark T., patient
• “The pharmacological rationale behind this combination is sound. However, it demands a higher degree of vigilance from the prescribing clinician regarding drug interactions, particularly with alpha-blockers, which are commonly prescribed to the same patient demographic. Patient education on contraindications, especially nitrates, is paramount.” – Clinical Pharmacist Review
• “It worked effectively, but the back pain side effect was quite pronounced for me, lasting almost a full day after use. I discussed this with my doctor, and we are considering adjusting the timing or potentially trying a different option.” – James L., patient