Viagra: Restore Confidence with Reliable Erectile Function
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Synonyms | |||
Similar products
Viagra (sildenafil citrate) is a prescription phosphodiesterase type 5 (PDE5) inhibitor clinically proven to treat erectile dysfunction (ED). It works by enhancing blood flow to the penile tissues upon sexual stimulation, facilitating the achievement and maintenance of an erection sufficient for satisfactory sexual activity. This medication has been a cornerstone of ED treatment since its approval, offering a well-understood mechanism of action and a substantial body of clinical evidence supporting its efficacy and safety profile for appropriate candidates.
Features
- Active Pharmaceutical Ingredient: Sildenafil citrate.
- Available Dosage Strengths: 25 mg, 50 mg, and 100 mg film-coated tablets.
- Standard Onset of Action: Approximately 30 to 60 minutes post-ingestion.
- Duration of Effect: Efficacy can last for up to 4 to 5 hours, sometimes longer depending on individual factors.
- Administration: Oral tablet, taken with or without food (though high-fat meals may delay absorption).
- Mechanism: Selective inhibition of cGMP-specific phosphodiesterase type 5 (PDE5), increasing cyclic guanosine monophosphate (cGMP) levels in the corpus cavernosum.
Benefits
- Achieves clinically significant improvement in erectile function, enabling sexual intercourse.
- Provides a predictable and reliable therapeutic window for planned sexual activity.
- Enhances overall sexual satisfaction and confidence for both the individual and their partner.
- Offers a non-invasive, oral treatment option with a well-established safety record.
- Can improve measures of psychological well-being and relationship quality associated with successful ED treatment.
Common use
Viagra is indicated for the treatment of erectile dysfunction, the recurrent inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. It is used on an as-needed basis prior to anticipated sexual activity. It is important for patients to understand that sexual stimulation is required for the medication to be effective; it does not cause spontaneous erections. Viagra is used by adult males and is not indicated for use by women, children, or adolescents.
Dosage and direction
The recommended starting dose for most patients is 50 mg taken approximately one hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. Dosing should be limited to a maximum of once per 24-hour period. The tablet should be swallowed whole with a glass of water. For older patients (over 65), those with hepatic impairment or severe renal impairment (creatinine clearance <30 mL/min), and those taking certain concomitant medications (e.g., potent CYP3A4 inhibitors like ritonavir), a starting dose of 25 mg is recommended.
Precautions
- A comprehensive medical history and physical examination should be conducted to diagnose ED, determine potential underlying causes, and identify appropriate treatment options before prescribing Viagra.
- Patients should be made aware that Viagra offers no protection against sexually transmitted diseases.
- Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease), or in conditions that may predispose them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia).
- Consider underlying cardiovascular status, as sexual activity carries a potential cardiac risk. Viagra is not a treatment for cardiovascular disease.
- Patients with bleeding disorders or active peptic ulceration should use Viagra with caution.
- Transient and mild decreases in blood pressure are a known effect; caution is advised in patients on antihypertensive therapy.
Contraindications
- Concomitant use of organic nitrates in any form (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite “poppers”) at any time. This combination can cause a severe, life-threatening drop in blood pressure.
- Hypersensitivity to sildenafil or any of the excipients in the formulation.
- Concomitant use with guanylate cyclase stimulators, such as riociguat, due to the risk of symptomatic hypotension.
- Men for whom sexual activity is inadvisable due to underlying cardiovascular status.
Possible side effect
Like all medicines, Viagra can cause side effects, although not everybody gets them. Most are mild to moderate and transient.
- Very Common (≥1/10): Headache, flushing.
- Common (≥1/100 to <1/10): Dyspepsia, nasal congestion, dizziness, visual disturbances (including blurred vision, cyanopsia [seeing a blue tinge], and increased light sensitivity).
- Uncommon (≥1/1,000 to <1/100): Hypotension, tachycardia, palpitations, syncope, hematuria, eye pain, retinal vascular disease, conjunctival hyperemia, erythema, priapism (prolonged and sometimes painful erection lasting more than 4 hours; requires immediate medical attention to prevent permanent tissue damage).
- Rare (≥1/10,000 to <1/1,000): Hypersensitivity reactions (including skin rash), sudden hearing loss, non-arteritic anterior ischemic optic neuropathy (NAION).
- Frequency not known: Seizures.
Drug interaction
- Nitrates: Absolute contraindication. Concomitant use can cause severe hypotension, myocardial infarction, or death.
- Alpha-blockers: Concomitant use can lead to symptomatic hypotension. A separation of dosing times is recommended, and Viagra should be initiated at the 25 mg dose if co-administered.
- Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, ritonavir, and clarithromycin can significantly increase sildenafil plasma concentrations. A maximum Viagra dose of 25 mg within a 48-hour period is recommended.
- Other PDE5 Inhibitors: Concomitant use with other ED treatments (e.g., tadalafil, vardenafil) is not recommended.
- Antihypertensives: Additive blood pressure-lowering effects may occur.
- Guanylate Cyclase Stimulators (e.g., Riociguat): Contraindicated due to additive hypotensive effects.
Missed dose
Viagra is not intended for scheduled daily dosing. It is taken on an as-needed basis. If a dose is missed, it can be taken at the next opportunity, ensuring that at least 24 hours have passed since the last dose. Do not take a double dose to make up for a missed one.
Overdose
In cases of overdose, the expected pharmacologic effects would be an exaggeration of the known side effects, primarily severe hypotension and syncope. Standard supportive measures should be employed, including placing the patient in the supine position with the legs elevated to manage hypotension. Hemodialysis is not expected to accelerate clearance, as sildenafil is highly protein-bound.
Storage
Store Viagra tablets at room temperature (15°C to 30°C or 59°F to 86°F). Keep the medication in its original blister pack to protect from light and moisture. Keep all medicines out of the sight and reach of children. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. It is not a substitute for a consultation with a qualified healthcare professional. A doctor must prescribe this medication after a thorough assessment of your medical history, current health status, and potential drug interactions. Do not start, stop, or change the dosage of any medicine before checking with your doctor.
Reviews
“After my prostate surgery, ED was a significant concern. My urologist prescribed Viagra 50mg. The effect is reliable and has allowed my wife and I to resume a normal sex life. The flushing and slight headache are noticeable but a small price to pay for the benefit.” – Mark T., 62
“As a cardiologist, I carefully evaluate my patients before considering any ED treatment. For appropriate candidates without contraindications, Viagra remains a first-line option with a predictable efficacy and safety profile that we have decades of experience with. Patient education on avoiding nitrates is paramount.” – Dr. Evans, Cardiologist
“I was initially hesitant, but the 25mg dose works perfectly for me with minimal side effects. It’s given me back a sense of normalcy and confidence I hadn’t felt in years.” – James L., 58