Pure Ascorbic Acid: The Essential Vitamin C for Optimal Health
| Product dosage: 60mg | |||
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Synonyms | |||
Ascorbic acid, the pure and scientifically-identified form of Vitamin C, is a fundamental micronutrient critical for numerous physiological functions. As a water-soluble vitamin, it must be obtained through diet or supplementation, as the human body cannot synthesize it endogenously. This compound serves as a potent antioxidant and an essential cofactor for enzymatic reactions involved in collagen synthesis, neurotransmitter production, and immune modulation. Its clinical significance spans from preventative health to adjunctive therapeutic applications, making it a cornerstone of nutritional biochemistry and evidence-based supplementation.
Features
- Pharmaceutical-grade L-ascorbic acid (the biologically active enantiomer)
- High-purity, crystalline powder or tablet formulation for precise dosing
- Water-soluble molecular structure ensuring efficient systemic absorption
- Standardized potency with batch-to-batch consistency
- Free from common allergens, artificial colors, and preservatives
- Shelf-stable with appropriate packaging to minimize oxidation
Benefits
- Supports robust immune function by enhancing leukocyte activity and interferon production
- Promotes collagen biosynthesis, essential for vascular integrity, skin health, and wound healing
- Acts as a powerful aqueous-phase antioxidant, neutralizing free radicals and reducing oxidative stress
- Facilitates the absorption of non-heme iron, aiding in the prevention of iron-deficiency anemia
- Contributes to neurological health through its role in catecholamine and carnitine synthesis
- May help maintain endothelial function and cardiovascular health via nitric oxide modulation
Common use
Ascorbic acid is commonly utilized both prophylactically and therapeutically across various clinical and subclinical contexts. It is frequently employed to prevent or treat Vitamin C deficiency states, such as scurvy, characterized by impaired collagen synthesis leading to bleeding gums, petechiae, and poor wound healing. In immunonutrition, it is used to support immune defense during periods of increased physiological demand, such as infection, trauma, or intense physical exertion. Dermatologically, it is incorporated into regimens for photoaging, hyperpigmentation, and supporting dermal matrix integrity. Additionally, it is often co-administered with iron supplements to enhance bioavailability in anemic patients and is used in some protocols for its potential modest antihypertensive and endothelial-protective effects.
Dosage and direction
The Recommended Dietary Allowance (RDA) for ascorbic acid is 90 mg/day for adult males and 75 mg/day for adult non-pregnant females, with an upper limit (UL) of 2000 mg/day for adults to prevent adverse gastrointestinal effects. Therapeutic doses may range from 200 mg to 1000 mg daily, divided into two or three doses to enhance absorption and maintain plasma saturation, as single doses above 200 mg exhibit reduced fractional absorption. For specific conditions—such as supportive care in critical illness, under medical supervision—doses may exceed standard recommendations. Administration with water, preferably with or after meals, can mitigate potential gastric irritation. Sustained-release formulations may be used to prolong plasma half-life and improve tolerance.
Precautions
Individuals with a history of oxalate nephrolithiasis should use caution, as ascorbic acid is metabolized to oxalate and may increase urinary excretion. Those with hemochromatosis, thalassemia, or other iron-overload disorders should avoid high doses due to enhanced non-heme iron absorption. Diabetic patients should monitor blood glucose levels, as in vitro studies suggest ascorbic acid may interfere with some blood glucose monitoring systems. Use in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency warrants supervision due to theoretical risk of hemolysis at very high doses. Pregnant and lactating women should not exceed the UL without medical advice.
Contraindications
Ascorbic acid is contraindicated in individuals with known hypersensitivity to any component of the formulation. It should not be used in patients with recurrent calcium oxalate kidney stones without medical supervision. Use is contraindicated concomitantly with certain chemotherapeutic agents (e.g., bortezomib) due to potential interference with drug mechanisms. It is also contraindicated prior to certain diagnostic tests (e.g., fecal occult blood tests, urinary glucose tests) as it may cause false-negative results.
Possible side effect
At recommended doses, ascorbic acid is generally well-tolerated. High doses (exceeding 1000–2000 mg/day) may lead to gastrointestinal disturbances such as diarrhea, nausea, abdominal cramps, and other osmotic effects. There is a dose-dependent increase in urinary oxalate excretion, which may elevate the risk of nephrolithiasis in predisposed individuals. Cases of acid reflux or heartburn have been reported. Very high doses may rarely cause headache, insomnia, or transient flushing. Topical formulations may cause mild irritation, stinging, or dryness in sensitive skin.
Drug interaction
Ascorbic acid may interact with several pharmacological agents. It can increase serum levels of aluminum-containing phosphate binders (e.g., aluminum hydroxide) and should not be taken simultaneously. It may reduce the anticoagulant effect of warfarin, though clinical significance is debated. Concomitant use with aspirin may increase urinary excretion of ascorbate and decrease salicylate levels. It can elevate plasma estrogen levels when taken with oral contraceptives or hormone replacement therapy. Ascorbic acid may diminish the therapeutic effect of certain protease inhibitors and chemotherapeutic agents. It is known to interfere with urine-based drug screenings and certain laboratory assays.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. Do not double the dose to make up for a missed one. Consistency in daily intake helps maintain adequate plasma levels, but occasional missed doses are unlikely to cause deficiency in well-nourished individuals with adequate reserves.
Overdose
Acute overdose of ascorbic acid is uncommon due to its water solubility and efficient renal clearance. Extremely high single doses may cause pronounced gastrointestinal distress, including severe diarrhea, nausea, and gastritis. Management is supportive and includes discontinuation, hydration, and symptomatic care. Chronic megadosing (consistently >3000 mg/day) may lead to increased oxalate production, predisposing to renal calculi, and in rare cases, iron overload in susceptible individuals. Hemodialysis is not typically indicated.
Storage
Store in a tightly closed container in a cool, dry place, protected from light and moisture to prevent oxidation. Ideal storage temperature is between 15–30°C (59–86°F). Keep away from heat sources and strong odors. Do not refrigerate unless specified by the manufacturer. Keep out of reach of children and pets.
Disclaimer
This information is provided for educational and informational purposes only and does not constitute medical advice. Ascorbic acid is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Individual requirements and responses may vary. Consult a qualified healthcare professional before starting any new supplement, especially if you have pre-existing medical conditions, are taking other medications, or are pregnant or breastfeeding. Do not disregard professional medical advice or delay seeking it based on content provided here.
Reviews
“As a clinical nutritionist, I recommend pharmaceutical-grade ascorbic acid to clients requiring precise dosing for immune or collagen support. Its predictability and purity are unmatched by many complex formulations.” — Maria M., Clinical Nutritionist
“Using 500 mg daily has significantly reduced my frequency of seasonal respiratory infections. I appreciate the simplicity and evidence behind the pure compound.” — James R., Regular User
“We use ascorbic acid in our research on oxidative stress markers. Its stability and well-documented pharmacokinetics make it ideal for controlled studies.” — Dr. Lena S., Research Scientist
“After bariatric surgery, my doctor put me on ascorbic acid to prevent deficiency. It’s easy to take and I’ve had no issues with tolerability.” — Susan T., Post-Surgical Patient
“I’ve incorporated topical ascorbic acid into my dermatology practice for photoprotection and anti-aging. The science supporting its role in collagen synthesis is robust.” — Dr. Ben K., Dermatologist