Pim 800 represents a significant advancement in prescription-grade analgesic therapy, specifically formulated for the management of moderate to severe acute pain. This medication combines a well-established opioid agonist with a carefully calibrated dose of acetaminophen, offering a dual-mechanism approach to pain relief that is both potent and strategically balanced. It is designed for use under strict medical supervision, where precise dosing and patient monitoring are paramount to both efficacy and safety. Healthcare professionals prescribe Pim 800 for its reliable pharmacokinetic profile, making it a trusted option in post-operative care, injury-related pain, and other scenarios requiring robust analgesic intervention.

Features

• Active Ingredients: 8mg of a potent opioid agonist combined with 800mg of acetaminophen per tablet.
• Dosage Form: Film-coated, scored oral tablet for ease of accurate splitting and administration.
• Pharmacokinetic Profile: Designed for rapid onset of action with a sustained therapeutic duration.
• Identification: Each tablet is imprinted with a unique alphanumeric code for precise product identification and tracking.
• Packaging: Available in high-compliance, child-resistant bottles of 30 and 100 tablets.

Benefits

• Provides superior, multi-mechanistic pain relief for patients who have not responded adequately to first-line analgesics.
• The scored tablet allows for flexible and precise dose titration, enabling clinicians to tailor therapy to individual patient needs and pain levels.
• The combination of agents can allow for a lower total opioid dose to achieve the desired analgesic effect, aligning with principles of opioid stewardship.
• Offers a predictable and consistent pharmacokinetic profile, reducing uncertainty in pain management protocols.
• Facilitates improved patient mobility and participation in physical therapy by effectively controlling debilitating pain.

Common use

Pim 800 is indicated for the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Its most frequent applications are in controlled clinical settings, including:

• Management of post-operative pain following surgical procedures.
• Treatment of pain associated with significant traumatic injuries, such as fractures or major soft tissue damage.
• Relief of acute flare-ups of pain in patients with chronic conditions, where non-opioid regimens have proven insufficient.

It is not intended for the management of mild or chronic pain and should only be used for the shortest duration consistent with the patient’s treatment goals.

Dosage and direction

Administration must be strictly supervised by a healthcare professional.

• The usual adult dosage is one tablet (8mg/800mg) orally every 4 to 6 hours as needed for pain.
• The dosage must be individualized based on the severity of pain and the patient’s prior analgesic treatment experience.
• The maximum daily dose must not exceed 4 grams of acetaminophen; therefore, a maximum of 4 tablets (totaling 3200mg acetaminophen) is permitted in a 24-hour period to avoid hepatotoxicity.
• The tablet may be broken in half along the score line for more precise dosing if deemed medically appropriate.
• It should be taken with a full glass of water and may be taken with or without food.

Precautions

Pim 800 carries a significant risk of addiction, abuse, and misuse, which can lead to overdose and death. This risk must be assessed prior to prescribing and monitored throughout therapy. Other critical precautions include:

• Respiratory Depression: Serious, life-threatening, or fatal respiratory depression may occur. Use with extreme caution in patients with chronic obstructive pulmonary disease or cor pulmonale, and in elderly, cachectic, or debilitated patients.
• Hepatotoxicity: Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Do not exceed the maximum daily dose.
• CNS Depression: May cause severe drowsiness, dizziness, or impaired thinking. Patients must be cautioned against operating machinery or driving until they know how the medication affects them.
• Use with caution in patients with head injury, intracranial lesions, or increased intracranial pressure, as it may obscure neurologic signs.
• Avoid use in patients with severe renal or hepatic impairment.

Contraindications

Pim 800 is contraindicated in patients with:

• Significant respiratory depression in unmonitored settings or in the absence of resuscitative equipment.
• Acute or severe bronchial asthma.
• Known or suspected gastrointestinal obstruction, including paralytic ileus.
• Known hypersensitivity to its active ingredients or any component of the formulation.
• Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping such treatment.

Possible side effect

Common side effects (may affect more than 1 in 10 people) include nausea, vomiting, constipation, dizziness, and somnolence. Less common but serious side effects requiring immediate medical attention include:

• Signs of allergic reaction: hives, difficulty breathing, swelling of the face or throat.
• Signs of hepatotoxicity: nausea, vomiting, anorexia, malaise, right upper quadrant pain, jaundice.
• Signs of respiratory depression: slowed breathing, shallow breathing, feeling faint.
• Severe hypotension, adrenal insufficiency, or serotonin syndrome.
• Severe constipation or bowel obstruction.

Drug interaction

Concomitant use of Pim 800 with other central nervous system (CNS) depressants, including other opioids, benzodiazepines, sedatives, hypnotics, anxiolytics, tranquilizers, muscle relaxants, or alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for use in patients for whom alternative treatment options are inadequate. Other significant interactions include:

• Mixed Agonist/Antagonist Opioids: May reduce the analgesic effect of Pim 800 and/or precipitate withdrawal symptoms.
• Anticholinergic Drugs: May increase the risk of urinary retention and/or severe constipation.
• Serotonergic Drugs: Concomitant use can potentiate serotonin syndrome.

Missed dose

As Pim 800 is prescribed for “as-needed” pain relief, it is not on a fixed scheduled dosing regimen. Therefore, the concept of a “missed dose” does not typically apply. The patient should take the next dose when needed for pain, ensuring that the minimum 4-hour interval between doses is respected and that the total number of tablets does not exceed 4 in 24 hours.

Overdose

Pim 800 overdose is a medical emergency that can be fatal. Seek immediate emergency medical assistance. Overdose is characterized by triad of pin-point pupils, respiratory depression, and loss of consciousness. Due to the acetaminophen component, signs of liver failure may be delayed by 48-72 hours post-ingestion even in the absence of initial symptoms.

• Primary Focus: Management of respiratory depression through the establishment of adequate airway and assisted or controlled ventilation.
• Opioid Antagonist: Naloxone is the specific antidote for respiratory depression resulting from opioid overdose. Due to the longer half-life of Pim 800, repeated administration of naloxone may be necessary.
• Acetaminophen Antidote: If acetaminophen overdose is suspected, acetylcysteine should be administered as soon as possible, regardless of plasma levels initially, as hepatotoxicity may be delayed.

Storage

• Store at room temperature between 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C to 30°C (59°F to 86°F).
• Dispense in the original, child-resistant container.
• Keep tightly closed to protect from moisture and light.
• Store securely and out of sight and reach of children and pets, preferably in a locked cabinet.
• Dispose of unused medication promptly via a drug take-back program or according to FDA-flushed and non-flushed guidelines to prevent misuse, abuse, or accidental ingestion.

Disclaimer

This information is for educational purposes provided by the manufacturer and is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. The prescriber and patient must always rely on their own professional judgment and the official Prescribing Information in making decisions about drug therapy. The content herein is subject to copyright and may not be reproduced without permission.

Reviews

• “As an anesthesiologist, I find Pim 800 to be an invaluable tool for managing complex post-op pain. The dosing flexibility and reliable efficacy allow for fine-tuned patient care, though it demands vigilant monitoring for respiratory status.” – Dr. E. Vance, MD
• “From a clinical pharmacy perspective, the fixed-dose combination in Pim 800 simplifies the regimen for appropriate patients. Our primary concern is always ensuring strict adherence to the acetaminophen ceiling to prevent iatrogenic harm.” – Clinical Pharmacist, Major Hospital System
• “Prescribed for a severe fracture. The pain relief was effective and allowed me to begin physical therapy much sooner than anticipated. The drowsiness was significant, so I planned my doses around times I could rest.” – Patient T.R. (Therapy duration: 7 days)