Elimite (permethrin) 5% cream is a topical scabicidal medication prescribed for the treatment of scabies infestations. As a synthetic pyrethroid, it exhibits potent parasiticidal activity against Sarcoptes scabiei var. hominis, the mite responsible for scabies. This prescription-strength formulation works through neurotoxic mechanisms that are highly selective for arthropods, ensuring effective eradication while maintaining a favorable safety profile for human use. Clinical studies demonstrate cure rates exceeding 90% when used as directed, making it a first-line therapeutic option recommended by dermatologists and infectious disease specialists worldwide.

Features

• Contains 5% permethrin as the active pharmaceutical ingredient
• Topical cream formulation for direct application to affected areas
• Synthetic pyrethroid compound with enhanced stability
• Prescription-only medication requiring professional diagnosis
• Single-application treatment in most cases
• Minimal systemic absorption when properly applied
• Stable at room temperature with two-year shelf life
• Available in 60g tubes containing sufficient medication for adult treatment

Benefits

• Provides complete eradication of scabies mites and eggs with proper application
• Rapid relief from intense itching typically within 24-72 hours after treatment
• Prevents transmission to household members and close contacts when used prophylactically
• Minimizes risk of secondary bacterial infections by eliminating the source of pruritus
• Requires only one application in most cases, enhancing treatment adherence
• Established safety profile with decades of clinical use and post-marketing surveillance

Common use

Elimite is primarily indicated for the treatment of scabies infestations in patients aged two months and older. The medication is applied from the neck down to the soles of the feet, covering all skin surfaces, with particular attention to areas between fingers and toes, wrists, axillae, external genitalia, and beneath fingernails. Healthcare providers may also recommend prophylactic treatment for household members and sexual contacts regardless of whether symptoms are present, as scabies transmission often occurs before clinical manifestations appear. The cream remains on the skin for 8-14 hours before being washed off with soap and water.

Dosage and direction

For scabies treatment: Apply a thin layer of Elimite cream to clean, dry skin from the neck to the soles of the feet, ensuring complete coverage of all skin surfaces. Pay special attention to skin folds, between fingers and toes, and beneath nails. Leave the cream on for 8-14 hours (typically overnight), then wash thoroughly with soap and water. Most patients require only one application, though a second treatment 7-14 days later may be necessary if new burrows or mites appear. For children aged 2 months to 5 years, also apply to the head and neck, avoiding the eyes and mouth. Use approximately 30g for an average adult application.

Precautions

• For external use only; avoid contact with eyes, nose, mouth, and other mucous membranes
• Do not apply to acutely inflamed skin or open wounds unless directed by a physician
• May cause temporary burning, stinging, or itching after application
• If severe irritation develops, wash off immediately and consult your healthcare provider
• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding
• Children may be more susceptible to skin irritation and systemic absorption
• Do not cover treated areas with occlusive dressings unless specifically instructed
• Wash all recently worn clothing, bedding, and towels in hot water and dry using high heat

Contraindications

• Known hypersensitivity to permethrin, other pyrethroids, or chrysanthemums
• History of allergic reaction to any component of the formulation
• Patients with pre-existing seizure disorders (theoretical risk of neurotoxicity)
• Application to neonates younger than two months of age
• Active cutaneous tuberculosis, varicella, or vaccinia infections
• Severe inflammatory skin conditions affecting large body surface areas

Possible side effects

Most common (≥1%):

• Temporary itching, burning, or stinging at application site
• Mild erythema, edema, or rash
• Numbness or tingling sensations

Less common (<1%):

• Contact dermatitis or allergic reactions
• Headache, dizziness, or fever
• Nausea or abdominal discomfort
• Respiratory difficulties in susceptible individuals

Rare (<0.1%):

• Paraesthesias (pins and needles sensation)
• Transient hair loss at application site
• Seizures (in patients with predisposing factors)

Drug interaction

No clinically significant drug interactions have been formally established with topical permethrin. However, theoretical considerations include:

• Potential increased systemic absorption when used with other topical medications that enhance skin permeability
• Possible enhanced neurotoxic effects when used concomitantly with other neurotoxic agents
• Reduced efficacy if applied immediately after bathing with oil-based products that might create a barrier
• No known interactions with systemic medications, though caution is advised with drugs that lower seizure threshold

Missed dose

As Elimite is typically administered as a single application, the concept of a “missed dose” does not apply in the conventional sense. If the application is washed off prematurely (before 8 hours), reapply immediately to ensure adequate exposure time. If the treatment is not administered at the planned time, apply as soon as possible and maintain the cream on skin for the full 8-14 hours. Do not apply more than two treatments within a 7-day period unless specifically directed by a healthcare provider.

Overdose

Topical overdose may occur through excessive application or accidental ingestion. Symptoms may include:

• Intensified local reactions: severe erythema, burning, or edema
• Systemic effects: nausea, vomiting, abdominal pain (if ingested)
• Neurological symptoms: dizziness, headache, fatigue (rare with topical use)
• In severe cases: muscle fasciculations, seizures, respiratory distress

Treatment: Remove cream by washing thoroughly with soap and water. For ingestion, seek immediate medical attention; gastric lavage and supportive care may be indicated. There is no specific antidote; management is symptomatic and supportive.

Storage

• Store at controlled room temperature (20-25°C or 68-77°F)
• Keep tube tightly closed when not in use
• Protect from excessive heat and direct sunlight
• Do not freeze
• Keep out of reach of children and pets
• Discard any unused product after treatment completion
• Do not use after expiration date printed on packaging

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Elimite is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual results may vary, and proper diagnosis by a physician is essential before beginning treatment. Always follow the specific instructions provided by your healthcare provider and read the complete prescribing information included with your medication. Report any adverse reactions to your physician and the appropriate regulatory authorities.

Reviews

Clinical studies involving over 2,000 patients demonstrate Elimite’s efficacy and safety profile. In randomized controlled trials, permethrin 5% cream showed superior efficacy compared to crotamiton and lindane, with cure rates of 89-95% after one application. Pediatric studies confirm safety in children over two months, with similar efficacy rates to adult populations. Post-marketing surveillance data from three decades of use support the favorable benefit-risk profile, with serious adverse events reported in less than 0.01% of patients. Dermatologists consistently rate permethrin as first-line therapy for scabies in national treatment guidelines.