Atacand (candesartan cilexetil) is an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension in adults. It works by blocking the action of certain natural substances that tighten blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. This medication may be used alone or in combination with other antihypertensive agents, offering a well-tolerated option for long-term management of high blood pressure. Clinical studies support its efficacy in reducing cardiovascular risk when used as part of a comprehensive treatment plan.

Features

• Active ingredient: candesartan cilexetil
• Available in tablet strengths: 4 mg, 8 mg, 16 mg, 32 mg
• Administration: oral, once or twice daily
• Onset of action: within 2 weeks, with full effect at 4 weeks
• Half-life: approximately 9 hours
• Excretion: primarily renal and biliary

Benefits

• Effectively lowers systolic and diastolic blood pressure
• Reduces strain on the heart and vascular system
• Demonstrates proven cardiovascular risk reduction in clinical trials
• Generally well-tolerated with a low incidence of side effects
• Suitable for monotherapy or combination treatment
• Once-daily dosing supports adherence

Common use

Atacand is primarily prescribed for the management of hypertension. It may be used as first-line therapy or as an add-on treatment when other antihypertensive agents provide insufficient control. In some cases, it may be indicated for heart failure treatment in combination with other therapies, though this requires specific medical supervision. The medication is not recommended for pediatric use except in specific circumstances under specialist guidance.

Dosage and direction

The recommended initial dose for most adults is 16 mg once daily. Dosage may be increased to 32 mg once daily based on blood pressure response. For patients with volume depletion or hepatic impairment, consider starting with 8 mg once daily. Tablets should be swallowed whole with a glass of water, with or without food. Consistency in dosing time is recommended to maintain stable blood levels. Dose titration should occur at intervals of at least 2 weeks.

Precautions

Monitor renal function and electrolytes periodically during treatment. Use caution in patients with renal impairment, hepatic dysfunction, or bilateral renal artery stenosis. May cause hyperkalemia, particularly in patients with renal impairment or diabetes. Not recommended during pregnancy due to potential fetal harm. Exercise caution in elderly patients who may be more sensitive to hypotensive effects. Avoid use in patients with severe congestive heart failure unless closely monitored.

Contraindications

Hypersensitivity to candesartan or any component of the formulation. Concomitant use with aliskiren in patients with diabetes. Pregnancy, particularly second and third trimesters. Severe hepatic impairment or biliary cirrhosis. History of angioedema related to previous ARB or ACE inhibitor therapy.

Possible side effects

Common (≥1%): dizziness, upper respiratory tract infection, back pain, pharyngitis. Less common: headache, fatigue, gastrointestinal disturbances, elevated liver enzymes. Rare but serious: angioedema, renal impairment, hyperkalemia, hypotension. Most side effects are mild and transient, often resolving with continued therapy. Report any persistent or severe symptoms to healthcare provider.

Drug interaction

Potassium supplements or potassium-sparing diuretics may increase risk of hyperkalemia. NSAIDs may reduce antihypertensive effect and worsen renal function. Lithium levels may increase when co-administered. Enhanced hypotensive effect with other antihypertensive agents. Caution with dual blockade of the renin-angiotensin system. Monitor closely when used with diuretics or other agents affecting blood pressure.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Maintain regular dosing schedule to ensure consistent blood pressure control. If multiple doses are missed, contact healthcare provider for guidance on resuming therapy.

Overdose

Symptoms may include hypotension, tachycardia, bradycardia, dizziness, and renal impairment. Management involves supportive care with volume expansion with normal saline. Hemodialysis may not be effective due to high protein binding. Monitor vital signs and electrolyte balance closely. Seek immediate medical attention if overdose is suspected.

Storage

Store at room temperature (15-30°C) in original container. Protect from light and moisture. Keep tightly closed and out of reach of children. Do not use after expiration date. Do not transfer to other containers as this may affect stability. Discard any tablets that appear discolored or damaged.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult with a qualified healthcare provider before starting or changing any medication regimen. Individual response to therapy may vary. Proper diagnosis and monitoring are essential for safe and effective treatment.

Reviews

Clinical trials demonstrate Atacand’s efficacy in reducing blood pressure with good tolerability profile. Many patients report satisfactory control with minimal side effects. Healthcare providers note its reliability in combination therapy and appreciate once-daily dosing convenience. Long-term studies support its cardiovascular protective benefits when used as directed under medical supervision.