Artvigil is a prescription medication containing armodafinil, the R-enantiomer of modafinil, designed to promote wakefulness in individuals with excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. As a eugeroic agent, it functions by selectively influencing neurotransmitters in the brain regions responsible for sleep-wake regulation, offering a refined mechanism of action compared to traditional stimulants. Its extended half-life and targeted activity make it a cornerstone in the management of hypersomnolence, providing sustained alertness without the pronounced euphoria or rebound fatigue typical of amphetamine-based therapies.

Features

• Active ingredient: Armodafinil (150 mg tablets)
• Pharmacological class: Eugeroic (wakefulness-promoting agent)
• Mechanism: Selective activation of hypothalamic wakefulness centers; dopamine reuptake inhibition
• Bioavailability: Approximately 80% following oral administration
• Half-life: 12–15 hours
• Onset of action: Within 1–2 hours post-ingestion
• Excretion: Primarily renal (≈80%), with minor hepatic metabolism
• Formulation: Film-coated, scored tablets for precise dosing

Benefits

• Promotes sustained wakefulness and alertness throughout the waking day
• Enhances cognitive functions including memory, focus, and executive processing
• Reduces excessive daytime sleepiness in diagnosed sleep disorders
• Minimizes the cognitive impairment associated with shift work sleep disruption
• Low abuse potential compared to traditional CNS stimulants
• Improves overall functional outcomes in occupational and social settings

Common use

Artvigil is primarily indicated for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA) (as adjunctive therapy to continuous positive airway pressure), and shift work sleep disorder (SWSD). It is used off-label in certain cases for attention deficit hyperactivity disorder (ADHD), fatigue associated with multiple sclerosis, and depression-related lethargy, though these uses lack full FDA approval and require careful clinical consideration.

Dosage and direction

The recommended dosage for Artvigil is 150 mg or 250 mg taken orally once daily in the morning, depending on the condition being treated and individual response. For narcolepsy or OSA: 150 mg or 250 mg upon waking. For SWSD: 150 mg taken approximately 1 hour prior to the start of the work shift. Tablets should be swallowed whole with water; they may be taken with or without food, though a high-fat meal may delay absorption. Dosage adjustments should be made under medical supervision based on efficacy and tolerability.

Precautions

Patients should be advised to avoid alcohol while taking Artvigil, as it may alter drug metabolism and increase side effects. Use with caution in those with cardiovascular disease, hypertension, or history of psychosis. Artvigil may reduce the effectiveness of hormonal contraceptives; alternative non-hormonal birth control methods are recommended during and for one month after discontinuation. It may impair ability to operate machinery or drive; patients should refrain from such activities until they know how the medication affects them.

Contraindications

Artvigil is contraindicated in patients with known hypersensitivity to armodafinil, modafinil, or any component of the formulation. It should not be used in those with symptomatic cardiovascular disease, history of left ventricular hypertrophy, or mitral valve prolapse. Use is also contraindicated in patients with severe hepatic impairment (Child-Pugh Class C). It is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Possible side effects

Common side effects (≥5%) include headache, nausea, dizziness, insomnia, anxiety, and dry mouth. Less frequently (1–5%), patients may experience palpitations, diarrhea, nervousness, or upper respiratory tract infection. Rare but serious adverse reactions include Stevens-Johnson syndrome, angioedema, multiorgan hypersensitivity reactions, and psychiatric symptoms such as aggression, depression, or hallucinations. Any severe or persistent side effects should be reported to a healthcare provider immediately.

Drug interaction

Artvigil is a moderate inducer of CYP3A4/5 and may reduce plasma concentrations of drugs metabolized by this enzyme, including cyclosporine, midazolam, triazolam, and certain statins. It may also inhibit CYP2C19, potentially increasing levels of drugs such as diazepam, phenytoin, or omeprazole. Concurrent use with monoamine oxidase inhibitors (MAOIs) is not recommended. Caution is advised when co-administering with warfarin, hormonal contraceptives, or other CNS stimulants.

Missed dose

If a dose is missed, it should be taken as soon as possible on the same day. However, if it is near the time of the next dose, the missed dose should be skipped to avoid double dosing and potential sleep disruption. Do not take two doses at once. Consistent daily timing is recommended to maintain stable therapeutic levels.

Overdose

Symptoms of overdose may include insomnia, restlessness, agitation, confusion, tachycardia, hypertension, and gastrointestinal distress. In severe cases, hallucinations or arrhythmias may occur. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage or activated charcoal may be considered if ingestion was recent. Cardiovascular and psychiatric status should be monitored closely in a medical facility.

Storage

Store at room temperature (20–25°C or 68–77°F), in a tightly closed container, away from light, moisture, and heat. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Dispose of unused medication via a drug take-back program or according to local regulations.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Artvigil is a prescription medication and should only be used under the supervision of a qualified healthcare professional. Individual response may vary. Always follow your physician’s instructions and read the accompanying patient information leaflet. Do not start, stop, or change the dosage without medical consultation.

Reviews

Clinical studies and patient reports generally indicate high satisfaction with Artvigil’s efficacy in promoting wakefulness and improving cognitive function. Many users note significant improvement in daytime alertness and quality of life, particularly those with shift work sleep disorder or narcolepsy. Some report mild side effects such as headache or dry mouth, which often subside with continued use. A minority of users experience sleep disturbances or anxiety, underscoring the importance of individualized dosing and medical supervision. Overall, it is regarded as a well-tolerated and effective agent in its class.