Alli (orlistat 60 mg) is the only FDA-approved over-the-counter weight loss aid that works by preventing the absorption of dietary fat. It is designed for use in conjunction with a reduced-calorie, low-fat diet and regular physical activity in adults with a body mass index (BMI) of 25 or higher. By blocking enzymes in the digestive system, Alli helps users manage their caloric intake more effectively, supporting sustainable weight management when used as directed under appropriate medical guidance.

Features

• Contains 60 mg of orlistat per capsule
• Non-systemic mode of action; works locally in the gastrointestinal tract
• FDA-approved for over-the-counter use in adults
• Gluten-free formulation
• Packaged with a customized weight loss support plan and dietary guidelines

Benefits

• Supports weight loss by blocking the absorption of approximately 25% of dietary fat
• Encourages adherence to healthier eating habits through tangible dietary feedback
• Can help reduce the risk of weight-related comorbidities when combined with lifestyle changes
• Provides a non-stimulant alternative to other weight management supplements
• Empowers users with educational resources for long-term weight maintenance
• Compatible with a structured, medically-supervised weight management program

Common use

Alli is commonly used by adults aged 18 and older who are overweight (BMI ≥ 25) as an adjunct to a comprehensive weight management strategy. It is typically incorporated into a daily routine that includes a nutritionally balanced, reduced-calorie diet containing no more than 30% of calories from fat, alongside increased physical activity. It is not intended for use in occasional overeating or without concurrent dietary modification.

Dosage and direction

Take one 60 mg capsule with water immediately before, during, or up to one hour after each main meal that contains fat. Do not exceed three capsules per day. If a meal is missed or contains no fat, the dose of Alli should be omitted. It is important to distribute daily fat intake evenly across meals and adhere to the recommended dietary fat limits to minimize gastrointestinal effects. Use as directed on the product label or as advised by a healthcare provider.

Precautions

• Not for use by individuals under 18 years of age.
• Should not be used by those with chronic malabsorption syndromes or cholestasis.
• Use with caution in patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis.
• May reduce the absorption of fat-soluble vitamins (A, D, E, K); a daily multivitamin supplement taken at least 2 hours before or after Alli is recommended.
• Inform your healthcare provider of use, especially if you take other medications or have underlying medical conditions.
• Discontinue use and consult a healthcare professional if you experience severe or persistent abdominal pain.

Contraindications

• Pregnancy or breastfeeding.
• Organ transplant recipients.
• Hypersensitivity to orlistat or any component of the formulation.
• Concurrent use with cyclosporine.
• Patients with reduced gallbladder function or previous gallbladder issues.

Possible side effects

Common side effects are largely gastrointestinal and may include:

• Oily spotting
• Gas with discharge
• Urgent bowel movements
• Fatty or oily stools
• Increased bowel movement frequency
• Incontinence

These effects are generally mild to moderate, decrease over time, and are often related to dietary fat intake. Less common side effects may include abdominal discomfort, rectal pain, or tooth/gum discomfort. Rarely, severe liver injury has been reported; discontinue use and seek medical attention if symptoms such as itching, yellowing eyes/skin, dark urine, or loss of appetite occur.

Drug interaction

Alli may interact with:

• Cyclosporine: avoid concomitant use.
• Warfarin: monitor INR closely as orlistat may affect vitamin K absorption.
• Amiodarone, levothyroxine, antiepileptic drugs: may require dose adjustment or monitoring.
• Fat-soluble vitamins and supplements: take at least 2 hours apart from Alli.
• Oral contraceptives: use additional non-hormonal contraception if experiencing severe diarrhea.

Consult a healthcare provider before starting Alli if taking any prescription medications.

Missed dose

If you miss a dose, take it with your next fat-containing meal. Do not double the dose to make up for a missed one.

Overdose

In case of suspected overdose, seek medical attention immediately. Symptoms may include severe abdominal discomfort, diarrhea, or nausea. There is no specific antidote; treatment should be symptomatic and supportive.

Storage

Store at room temperature (20–25°C or 68–77°F). Keep the bottle tightly closed and protect from moisture and light. Keep out of reach of children and pets.

Disclaimer

This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Use only as directed and in combination with a healthy lifestyle. Consult a healthcare professional before use if you have any medical conditions or are taking other medications. Read and follow all label instructions.

Reviews

Many users report successful weight loss when using Alli as part of a committed dietary and exercise plan. Clinical studies support its efficacy, showing that users can lose 50% more weight compared to diet and exercise alone. Common feedback highlights the product’s role in encouraging mindful eating, though some note gastrointestinal side effects during the initial adjustment period. Overall, adherence to a low-fat diet is critical for both effectiveness and tolerability.