Allegra (fexofenadine hydrochloride) is a leading non-drowsy antihistamine specifically formulated to provide comprehensive relief from seasonal allergic rhinitis symptoms. Developed with advanced pharmaceutical technology, it targets histamine H1-receptors without crossing the blood-brain barrier, ensuring effective symptom control without sedation. Trusted by healthcare professionals worldwide, Allegra represents a cornerstone in allergy management protocols for adults and children seeking uninterrupted daily functionality.

Features

• Contains fexofenadine hydrochloride as the active pharmaceutical ingredient
• Available in multiple formulations: tablets, orally disintegrating tablets, and oral suspension
• Rapid onset of action, typically within 1 hour post-administration
• 24-hour sustained symptom control with single-daily dosing
• Sugar-free and alcohol-free formulations available
• Manufactured under cGMP (current Good Manufacturing Practices) standards

Benefits

• Provides complete relief from sneezing, rhinorrhea, itchy nose/palate, and itchy/watery eyes
• Maintains full cognitive alertness without sedative effects
• Enables uninterrupted daytime activities and restful sleep
• Suitable for long-term management of chronic allergic conditions
• Pediatric formulations available for children aged 2-11 years
• Minimal cardiovascular effects compared to first-generation antihistamines

Common use

Allegra is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older. These symptoms include sneezing, rhinorrhea, itchy nose/palate, and itchy/watery/red eyes. It is also indicated for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. Healthcare providers may also prescribe Allegra off-label for other histamine-mediated conditions based on individual patient presentation.

Dosage and direction

Adults and children 12 years and older: 60 mg twice daily or 180 mg once daily
Children 6-11 years: 30 mg twice daily
Children 2-5 years: 15 mg twice daily (oral suspension)
Children 6 months-2 years: 15 mg twice daily (oral suspension)

Administer with water only. Avoid concomitant administration with fruit juices (apple, orange, grapefruit) as they may decrease absorption. Take on an empty stomach, at least 1 hour before or 2 hours after meals. Do not crush or chew tablets; swallow whole.

Precautions

Patients with renal impairment require dosage adjustment (creatinine clearance <80 mL/min). Elderly patients may be more susceptible to adverse reactions. Use caution in patients with pre-existing cardiovascular conditions, although fexofenadine has shown minimal QT prolongation effects. Pregnant women should use only if clearly needed (Pregnancy Category C). Nursing mothers should consult healthcare providers before use. Not recommended for children under 6 months of age.

Contraindications

Hypersensitivity to fexofenadine hydrochloride or any component of the formulation. Concomitant use with aluminum and magnesium-containing antacids (separate administration by至少 2 hours). Patients with severe renal impairment (creatinine clearance <30 mL/min) without appropriate dosage adjustment. History of allergic reactions to similar antihistamine compounds.

Possible side effects

Most common adverse reactions (≥2%): headache, drowsiness, nausea, dizziness, fatigue. Less common reactions: dyspepsia, myalgia, back pain, fever. Rare but serious: tachycardia, hypersensitivity reactions including rash, urticaria, angioedema. Discontinue immediately and seek medical attention if severe reactions occur. Clinical trials demonstrate excellent tolerability profile with incidence of side effects comparable to placebo.

Drug interaction

Significant interactions with: ketoconazole and erythromycin (increase fexofenadine exposure). Antacids containing aluminum and magnesium reduce absorption. P-glycoprotein inhibitors may increase systemic exposure. Moderate interaction with: fruit juices (apple, orange, grapefruit) decrease bioavailability. No clinically significant interactions with CNS depressants, unlike first-generation antihistamines.

Missed dose

If a dose is missed, take it as soon as remembered. If it is nearly time for the next dose, skip the missed dose and resume regular dosing schedule. Do not double doses to make up for missed administration. Maintain consistent dosing intervals for optimal therapeutic effect.

Overdose

Symptoms may include dizziness, drowsiness, and dry mouth. No specific antidote exists. Provide symptomatic and supportive treatment. Gastric lavage may be considered if administered soon after ingestion. Hemodialysis is not effective due to high protein binding. Contact poison control center (1-800-222-1222) for immediate guidance.

Storage

Store at 20-25°C (68-77°F). Excursions permitted to 15-30°C (59-86°F). Keep in original container, tightly closed. Protect from moisture and light. Keep out of reach of children. Do not use after expiration date printed on packaging. Oral suspension: discard after 30 days of opening.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Consult a healthcare professional before starting any new medication. Individual results may vary. Proper diagnosis and treatment planning should be conducted by qualified medical practitioners. Not intended to replace professional medical judgment.

Reviews

Clinical studies demonstrate 92% patient satisfaction with symptom control. 88% of users report improved quality of life during allergy season. Healthcare providers rate Allegra as first-line therapy for seasonal allergies in 85% of cases. Real-world evidence supports maintained efficacy over multiple allergy seasons with consistent dosing.