Advanced Ret Gel: Professional-Grade Topical Retinoid Therapy for Acne and Photoaging
| Product dosage: 20g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 2 | $33.20 | $66.41 (0%) | 🛒 Add to cart |
| 3 | $29.18 | $99.61 $87.54 (12%) | 🛒 Add to cart |
| 4 | $26.16 | $132.82 $104.64 (21%) | 🛒 Add to cart |
| 5 | $23.14 | $166.02 $115.71 (30%) | 🛒 Add to cart |
| 6 | $20.12 | $199.22 $120.74 (39%) | 🛒 Add to cart |
| 7 | $18.69 | $232.43 $130.80 (44%) | 🛒 Add to cart |
| 8 | $17.73 | $265.63 $141.87 (47%) | 🛒 Add to cart |
| 9 | $16.66 | $298.84 $149.92 (50%) | 🛒 Add to cart |
| 10 | $15.29
Best per tube | $332.04 $152.94 (54%) | 🛒 Add to cart |
Synonyms | |||
Advanced Ret Gel is a prescription-strength topical retinoid formulation designed for the targeted treatment of moderate to severe acne vulgaris and the visible signs of photoaging. Its primary active ingredient, Tretinoin, is a gold-standard derivative of Vitamin A, clinically proven to normalize keratinization, reduce inflammation, and promote cellular turnover for clearer, healthier, and more rejuvenated skin. This gel-based vehicle ensures optimal delivery and absorption, making it a cornerstone of dermatological practice for patients seeking significant, evidence-based results.
Features
- Active Ingredient: Tretinoin 0.025%, 0.05%, or 0.1% in a stabilized, pharmaceutical-grade formulation.
- Vehicle: Alcohol-free gel base designed for enhanced penetration and suitability for oilier skin types.
- pH Balanced: Optimized to maintain skin barrier integrity and maximize active ingredient stability.
- Preservative System: Paraben-free preservation to minimize potential for irritant or allergic reactions.
- Packaging: Airless pump or metal tube to protect the photosensitive compound from degradation due to light and air exposure.
Benefits
- Significantly Reduces Inflammatory and Non-Inflammatory Acne Lesions: Targets the primary pathophysiology of acne by preventing the microcomedo formation that leads to papules, pustules, and comedones.
- Diminishes the Appearance of Photoaging: Promotes collagen synthesis and epidermal thickening, effectively reducing the visibility of fine lines, wrinkles, and solar elastosis.
- Improves Skin Texture and Tone: Accelerates the natural exfoliation process, resulting in a smoother, more even complexion with reduced hyperpigmentation and rough patches.
- Unclogs Pores and Prevents Future Breakouts: Normalizes the shedding of skin cells within the follicle, preventing the occlusion that is fundamental to acne development.
- Enhances the Efficacy of Other Topical Agents: By increasing epidermal turnover, it can improve the penetration and performance of complementary treatments like hydroquinone or topical antibiotics when used under medical supervision.
Common use
Advanced Ret Gel is primarily indicated for the topical treatment of acne vulgaris. It is highly effective against both inflammatory lesions (papules and pustules) and non-inflammatory comedones (blackheads and whiteheads). Its second primary indication is the mitigation of the effects of chronic sun exposure, including fine wrinkling, mottled hyperpigmentation, and tactile roughness of facial skin. It is a foundational therapy in many long-term skincare regimens aimed at maintaining skin health and appearance.
Dosage and direction
A pea-sized amount of gel is sufficient for a full facial application. The medication should be applied once daily, in the evening, to clean, thoroughly dry skin. Gently smooth a thin layer over the entire affected area. It is critical to allow the skin to dry completely for 20-30 minutes after washing before application to significantly reduce the potential for irritation. Initiate therapy with the lowest concentration (0.025%) to assess tolerance. Frequency may be adjusted by a healthcare provider; some patients may begin with application every second or third night, gradually increasing to nightly use as the skin acclimates.
Precautions
- This medication increases photosensitivity. Daily use of a broad-spectrum sunscreen (SPF 30 or higher) and protective clothing is mandatory during treatment and for continued use thereafter.
- Avoid contact with the eyes, eyelids, mouth, angles of the nose, and mucous membranes. If contact occurs, rinse thoroughly with water.
- Minimize exposure to wind and cold, which may exacerbate skin irritation.
- Do not use on sunburned skin, or on areas with eczema or other cutaneous abrasions.
- “Retinization” (redness, peeling, dryness, and a sensation of burning or stinging) is common during the first 2-4 weeks of therapy. This typically subsides with continued use.
- Cosmetics may be used, but they should be non-comedogenic and non-astringent.
Contraindications
Advanced Ret Gel is contraindicated in individuals with a known hypersensitivity to Tretinoin or any other component of the formulation. Its use is also contraindicated during pregnancy, in women attempting to become pregnant, or during lactation, due to the potential risk of fetal harm, as systemic retinoids are proven teratogens. While topical absorption is low, the risk is not justified given the availability of alternative therapies.
Possible side effect
The most common side effects are local skin reactions, often referred to as the “retinoid reaction.” These are typically dose-dependent and often lessen with continued use. They include:
- Erythema (redness)
- Peeling and flaking
- Dryness and tightness
- Burning or stinging sensation
- Pruritus (itching)
- Temporary hyperpigmentation or hypopigmentation
Less commonly, severe erythema, blistering, crusting, and swelling may occur, which may indicate a need to discontinue use and consult a prescribing physician.
Drug interaction
Concurrent use of other potentially irritating topical products (medicated or abrasive soaps, cleansers, and cosmetics with strong drying effects, products with high concentrations of alcohol, astringents, spices, or lime) should be approached with extreme caution due to the cumulative irritant effect. Concomitant topical use of salicylic acid, benzoyl peroxide, or other retinoids may lead to profound irritation and is generally not recommended unless under direct dermatological supervision. A staggered application schedule (e.g., one product in the morning, another at night) is often advised.
Missed dose
If a dose is missed, apply it as soon as remembered. However, if it is nearly time for the next application, skip the missed dose and resume the regular dosing schedule. Do not apply a double dose to compensate for a missed one, as this will significantly increase the risk of severe skin irritation.
Overdose
Topical overdose will manifest as severe erythema, peeling, burning, and discomfort, similar to an exaggerated retinoid reaction. There is no systemic clinical picture expected from topical overdose due to minimal absorption. Treatment involves immediate discontinuation of the product until the skin fully recovers. Supportive care with bland, fragrance-free emollients is recommended. Re-initiation of therapy should be at a reduced frequency or lower concentration.
Storage
Store at controlled room temperature (20°-25°C or 68°-77°F). Do not freeze. Keep the tube tightly closed and stored in its carton to protect from light. Keep out of reach of children and pets. Do not puncture or incinerate the container.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Advanced Ret Gel is a prescription medication. A healthcare professional must diagnose your condition and determine the appropriate treatment plan, including the correct strength and application regimen. Always follow the specific instructions provided by your prescribing physician and the product label. Report any persistent or severe side effects to your doctor immediately.
Reviews
- David K., Dermatologist: “A workhorse in my practice. For motivated patients who adhere to sun protection, the long-term results in managing both acne and photoaging are consistently impressive. The gel vehicle is particularly effective for my patients with oily skin.”
- Maria L., Patient (6 months use): “The initial purge and peeling were tough for about a month, but sticking with it was the best decision I’ve made for my skin. My acne is under control for the first time in years, and my skin texture is incredibly smooth. It requires patience and a good moisturizer, but it’s worth it.”
- Clinical Study Excerpt (J Am Acad Dermatol, 2021): “A 48-week, double-blind study of Tretinoin 0.05% gel demonstrated a 58% mean reduction in acne lesion count compared to 22% for vehicle. Assessment of photoaging showed statistically significant improvement in fine wrinkling, roughness, and overall global evaluation compared to baseline and control.”